Beilstein J. Org. Chem.2016,12, 835–845, doi:10.3762/bjoc.12.82
display promising properties in asymmetric catalysis [19][20][21][22].
In our ongoing forensicchemistry programme directed toward the identification and synthesis of novel byproducts of illegally produced amphetamine analogues, we described the synthesis of several new nitrogen heterocycles. Among them
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Graphical Abstract
Figure 1:
Types of aryl pyridines and pyrimidines already prepared in our group [23-27].
Beilstein J. Org. Chem.2013,9, 641–646, doi:10.3762/bjoc.9.72
analytical methods. Using NMR we show that GHB glucuronide 2 is highly stable towards aqueous hydrolysis within the pH range normally observed for urine even at elevated temperature.
Keywords: analytical chemistry; cabohydrate chemistry; forensicchemistry; glucuronide; γ-hydroxybutyric acid; metabolite
demonstrated to be highly stabile towards aqueous hydrolysis within the pH range normally observed for urine even at elevated temperature for several days, making it suitable for method development within analytical and forensicchemistry.
Experimental
General
For reactions conducted under anhydrous conditions
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Graphical Abstract
Figure 1:
Hypothesised glucuronidation of GHB (1) by UDP-glucuronosyltransferase to give glucuronide 2. UDP =...